New Approach Will Improve Cancer Therapy
In the June issue of ACS Chemical Biology, there is a report on a new strategy for enabling anti-cancer drugs to kill only cancer cells, without putting the normal cells in the body at harm.
The new approach would allow anticancer drugs to accumulate in both normal and malignant cells. The drugs, however, would be tweaked by giving them “basic” chemical properties. In chemistry, “basic” means an alkaline substance like baking soda or laundry detergent, which has properties opposite those of acidic substances. Normal cells simply isolate anti-cancer drugs with basic properties, greatly reducing the toxic effects. Cancer cells, in contrast, have an impaired ability to isolate basic substances, and get hit with a full blast of toxicity.
This approach could offer substantial benefits to cancer patients which will allow then to tolerate higher and more effective doses of chemotherapy before normal cells are damaged to an extent that causes serious side effects and cessation of therapy.
Read more at ACS press release.
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