Risk of Colorectal Cancer in Long-term Smokers, May Not be Reduced by Aspirin and Other NSAIDS
Though it is widely known that aspirin (and other nonsteroidal anti-inflammatory drugs, or NSAIDS) use may reduce the risk of colorectal cancer by up to 40%, this may not extend to long-term smokers who are already at an increased risk of the disease.
These are the conclusions derived from a population-based study led by researchers at Fred Hutchinson Cancer Research Center.
In the same study, the researchers also found that the highest risk of colon cancer is among long-term smokers of 20 or more years who had never used NSAIDS and that smokers who used NSAIDs were still at an approximate 30 percent higher risk of colon cancer than nonsmokers.
“Smoking has been linked to a modestly increased risk of colorectal cancer, and use of NSAIDs has been shown to significantly decrease the risk of colorectal cancer. We wanted to see if NSAIDs could counteract the adverse effects of smoking with regard to colorectal-cancer risk, and whether these associations differed by tumor characteristics,” she said.
Study findings appear in the July 1 issue of Cancer Research.
Source: FHCRC News
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