DMS Researchers Figured out Arsenite’s Unique Mechanism against Rare Leukemia
A new mechanism by which arsenite (a form of arsenic) acts in the treatment of a rare cancer called acute promyelocytic leukemia (APL) have been identified by researchers at Dartmouth Medical School (DMS).
APL is caused by the swapping of chromosomes 15 and 17, which forms a fusion protein. This fusion protein prevents certain blood cells from maturing and leads to an accumulation of immature leukemia cells.
Researchers found that arsenite causes rapid destabilization of the lysosome in cells, and that breaks the lysosome apart, releasing enzymes that destroy these particular kinds of leukemia cells.
This study has been published in the January 3 issue of the Journal of the National Cancer Institute.
Read more details from the press release.
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Tags: acute-promyelocytic-leukemia, arsenite, leukemiaRelated Stories
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