Angiotensin-Converting Enzyme (ACE) Can Protect From Tumor Growth
Angiotensin-converting enzyme (ACE) - commonly responsible in the regulation of blood pressure and a common therapeutic target for hypertension - has now been found to provide protection from tumor growth when strongly expressed in immune cells.
When injected with aggressive melanoma cells, normal mice developed large melanoma tumors whereas ACE 10/10 mice developed only very small tumors.
The resistance of ACE 10/10 mice to melanoma growth was confirmed using several different melanoma cell lines and by using different strains of mice expressing high levels of ACE in macrophages.
Interestingly, the small tumors of ACE 10/10 mice contained significantly higher numbers of white blood cells, suggesting a large anti-tumor immune response.
Related report on such findings appears in the June issue of the American Journal of Pathology.
Also, ACE has been found to play roles in fertility, immune cell development, and atherosclerosis, with a few studies suggesting a role in the generation of an effective immune response.
Find more details from the full report.
Tags: Angiotensin-Converting-Enzyme-(ACE), melanoma, tumor-growthRelated Stories
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